Listening to music induces powerful modulation activity on the mesolimbic pathway, impacts the nucleus accumbens and ventral tegmental area, as well as the hypothalamus and insula. The process of brain neuroplasticity in its relationship with music is a part of enhancing cognitive ability or intelligence in the form of auditory intelligence. Listening to music including in elderly associates with an improvement of brain plasticity, which is beneficial to stimulate cognitive function. Music can vibrate and resonate rhythm in our nature, in which as a metaphor, every cell in our body plays a role as a rhythmical sound resonator. The three major pearls of wisdom consist of Parahyangan or the harmony of life between human with God, Pawongan or the harmony of life between human with each other, and Palemahan or the harmony of life between humans and their natural surroundings. In Hindu religion, the philosophy of life is called Tri Hita Karana, which refers to a harmonious relationship that manifests happiness. The balance between brain, body, and soul is an integral part of human life.